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与主动脉脉搏波成分相关的死亡率和心血管终点:个体参与者荟萃分析
来源: | 作者:李 燕 教授 等 | 发布时间: 2024-06-06 | 319 次浏览 | 分享到:


背景:波分离分析可以对主动脉脉搏波成分进行个性化评估。之前的研究主要集中在压力高度上,结果总体上是积极的,但结果有所不同。在本分析中,我们评估了前向和后向脉搏波压力(P for和 P ref)与预期心血管终点的关联,并对达到压力峰值的时间(T for和 T ref)进行了扩展分析。

方法:参与者纳入了 3 个 IDCARS(国际中央动脉特性风险分层数据库)队列(阿根廷、比利时和芬兰)年龄≥20 岁且具有有效脉搏波分析和随访数据的数据。使用 SphygmoCor 仪器进行主动脉脉搏波分析,并使用三角法进行脉搏波分离。主要终点包括心血管死亡率和非致命性心脑血管事件。使用多变量调整的 Cox 回归来计算风险比。 

结果:总共分析了 2206 名参与者(平均年龄 57.0 岁;55.0% 为女性)。P for、P ref、T for和 T for /T ref的平均值±SD分别为 31.0±9.1 mm Hg、20.8±8.4 mm Hg、130.8±35.5 和 0.51±0.11。在中位随访 4.4 年中,146 名 (6.6%) 参与者经历了主要终点。P  TT /T ref每增加 1 个 SD,与 27% (95% CI, 1.07–1.49)、25% (95% CI, 1.07–1.45) 和 32% (95% CI) 相关。CI,1.12–1.56) 风险分别较高。将 T for和 T for /T ref添加到现有风险模型改进了模型预测(ΔUno's C,0.020;P <0.01)。

结论:脉搏波中的信息可预测复合心血管终点,其中 T for /T ref显示出显着改善在风险预测方面。前向和后向压力峰值的时间比率可能有助于评估后负荷的增加并表明心血管风险的增加。

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2024年学术会议

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2024中国高血压学术年会暨海峡两岸医药卫生交流协会高血压专业委员会学术年会暨国家心血管病中心高血压专病医联体学术年会


会议名称2024中国高血压学术年会暨海峡两岸医药卫生交流协会高血压专业委员会学术年会暨国家心血管病中心高血压专病医联体学术年会

会议地址: 中国北京 , 北京国际会议中心(北京市朝阳区北辰东路8号)

会议时间2024 年 7 月6 日



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